Evaluation physicochimique de l’exposition au cadmium chez les insuffisants rénaux chroniques par spectrophotométrie d’absorption atomique

Abstract

Introduction Interest in cadmium as an agent detrimental to human health has increased over the past decades. There are concerns about the spread of heavy metals in the environment, and human activities are one of the most important factors in their spread. These agents have a long half-life in the environment. Applied in different fields, ML are part of our daily lives. Material and method We sought to verify if there is a relationship between blood levels of Cd and the progressive stage of chronic renal failure . Cadmium pollution has become a real problem threatening our ecosystems, with detrimental effects on crop production and biodiversity. In our study we recruited 322 adult patients with chronic renal failure including 13% with mild CKD, 28.9% moderate, 11.5% severe, and 46.6% Terminal (hemodialysed). Results The average age of the cohort was 62.18 years ±0.78 and women 52% of all patients, including 28.60% aged between 56 and 76 years. The highest CRF frequencies 50% are between 55 and 75 years old while only 3.2% were between 16 and 36 years old. 43% of patients consume mineral water and 57% tap water. 37.8% of patients had diabetic nephropathy as etiology, 32.4% hypertension, 5.4% polycystosis and 24.3% of undetermined cause. As noted in our study, after analysis by logistic regression, the stage factor is the only risk factor that most influences the blood cadmium level, the odds ratio (OR) is equal to 10.025, the difference between the different stages of the The IRC is significant (p=0.00), concluding that there is a 10-fold risk of increasing the probability of having an elevated Cd level in an advanced stage patient. Conclusion Female gender, smoking, and end-stage CKD were associated with elevated blood Cd levels. These factors were also independently correlated with elevated blood Cd, including CR patients without dialysis, non-smokers, and male patients.